| Reaction Details |
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 | Report a problem with these data |
| Target | Major prion protein |
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| Ligand | BDBM41064 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) |
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| IC50 | 1181±n/a nM |
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| Citation |  PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Major prion protein |
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| Name: | Major prion protein |
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| Synonyms: | ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27671.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_158887 |
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| Residue: | 253 |
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| Sequence: | MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG
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| BDBM41064 |
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| n/a |
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| Name | BDBM41064 |
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| Synonyms: | Cyclohexanecarboxylic acid N'-[2-(2-ethyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide | MLS000556663 | N'-[2-(2-ethylquinazolin-4-yl)sulfanylacetyl]cyclohexanecarbohydrazide | N'-[2-(2-ethylquinazolin-4-yl)sulfanylethanoyl]cyclohexanecarbohydrazide | N'-[2-[(2-ethyl-4-quinazolinyl)thio]-1-oxoethyl]cyclohexanecarbohydrazide | N'-[2-[(2-ethylquinazolin-4-yl)thio]acetyl]cyclohexanecarbohydrazide | SMR000172939 | cid_1435013 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N4O2S |
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| Mol. Mass. | 372.484 |
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| SMILES | CCc1nc(SCC(=O)NNC(=O)C2CCCCC2)c2ccccc2n1 |
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| Structure | 
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