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TargetMajor prion protein
LigandBDBM47306
Substrate/Competitorn/a
Meas. Tech.TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50 875.59±n/a nM
Citation PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay(2014)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Major prion protein
Name:Major prion protein
Synonyms:ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:PROTEIN
Mol. Mass.:27671.97
Organism:Homo sapiens (Human)
Description:ChEMBL_158887
Residue:253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG
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  Blast E-value cutoff:
BDBM47306
n/a
NameBDBM47306
Synonyms:2-[(5-cyano-4-oxidanylidene-6-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanyl]-N-(methylcarbamoyl)ethanamide | 2-[(5-cyano-4-oxo-6-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanyl]-N-(methylcarbamoyl)acetamide | 2-[(5-cyano-4-oxo-6-thiophen-2-yl-1H-pyrimidin-2-yl)thio]-N-(methylcarbamoyl)acetamide | 2-[[5-cyano-4-keto-6-(2-thienyl)-1H-pyrimidin-2-yl]thio]-N-(methylcarbamoyl)acetamide | MLS000705748 | N-({[5-cyano-6-oxo-4-(2-thienyl)-1,6-dihydro-2-pyrimidinyl]sulfanyl}acetyl)-N'-methylurea | SMR000231787 | cid_1817440
TypeSmall organic molecule
Emp. Form.C13H11N5O3S2
Mol. Mass.349.388
SMILESCNC(=O)NC(=O)CSc1nc(-c2cccs2)c(C#N)c(=O)[nH]1
Structure
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