Ki Summary

Reaction Details

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Target

Major prion protein

Ligand

BDBM114399

Substrate/Competitor

n/a

Meas. Tech.

TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)

IC50

2084±n/a nM

Citation

PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay(2014)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Major prion protein

Name:

Major prion protein

Synonyms:

Type:

PROTEIN

Mol. Mass.:

27671.97

Organism:

Homo sapiens (Human)

Description:

ChEMBL_158887

Residue:

253

Sequence:

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG

BDBM114399

n/a

Name

BDBM114399

Synonyms:

4'-(1-benzofuran-2-carbonyl)-1-ethyl-3'-hydroxy-1'-(3-morpholin-4-ylpropyl)spiro[indole-3,5'-pyrrole]-2,2'-dione | 4'-(1-benzofuran-2-ylcarbonyl)-1-ethyl-1'-(3-morpholin-4-ylpropyl)-3'-oxidanyl-spiro[indole-3,5'-pyrrole]-2,2'-dione | 4'-[2-benzofuranyl(oxo)methyl]-1-ethyl-3'-hydroxy-1'-[3-(4-morpholinyl)propyl]spiro[indole-3,5'-pyrrole]-2,2'-dione | 4-(benzofuran-2-carbonyl)-1'-ethyl-3-hydroxy-1-(3-morpholinopropyl)spiro[3-pyrroline-5,3'-indoline]-2,2'-quinone | MLS000762609 | SMR000438209 | cid_3363660

Type

Small organic molecule

Emp. Form.

C29H29N3O6

Mol. Mass.

515.5571

SMILES

CCN1C(=O)C2(C(C(=O)c3cc4ccccc4o3)C(=O)C(=O)N2CCCN2CCOCC2)c2ccccc12

Structure