Ki Summary

Reaction Details

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Target

Methyl-CpG-binding domain protein 2

Ligand

BDBM114638

Substrate/Competitor

n/a

Meas. Tech.

TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide

IC50

17055±n/a nM

Citation

PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay(2013)[AID]

More Info.:

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Methyl-CpG-binding domain protein 2

Name:

Methyl-CpG-binding domain protein 2

Synonyms:

MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

43278.74

Organism:

Homo sapiens (Human)

Description:

gi_21595776

Residue:

411

Sequence:

MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRG
RGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGG
APRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF
SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLN
TTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQII
KTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCK
AFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA

BDBM114638

n/a

Name

BDBM114638

Synonyms:

4-(3-Dimethylamino-propylamino)-benzo[h]quinoline-3-carboxylic acid ethyl ester | 4-[3-(dimethylamino)propylamino]-3-benzo[h]quinolinecarboxylic acid ethyl ester | 4-[3-(dimethylamino)propylamino]benzo[h]quinoline-3-carboxylic acid ethyl ester | MLS001202447 | SMR000517833 | cid_1561354 | ethyl 4-[3-(dimethylamino)propylamino]benzo[h]quinoline-3-carboxylate

Type

Small organic molecule

Emp. Form.

C21H25N3O2

Mol. Mass.

351.4421

SMILES

CCOC(=O)c1cnc2c(ccc3ccccc23)c1NCCCN(C)C

Structure