Ki Summary

Reaction Details

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Target

Methyl-CpG-binding domain protein 2

Ligand

BDBM114640

Substrate/Competitor

n/a

Meas. Tech.

TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide

IC50

10248±n/a nM

Citation

PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay(2013)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Methyl-CpG-binding domain protein 2

Name:

Methyl-CpG-binding domain protein 2

Synonyms:

MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

43278.74

Organism:

Homo sapiens (Human)

Description:

gi_21595776

Residue:

411

Sequence:

MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRG
RGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGG
APRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF
SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLN
TTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQII
KTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCK
AFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA

BDBM114640

n/a

Name

BDBM114640

Synonyms:

2-[2,4-diphenyl-6-(p-tolyl)pyridin-1-ium-1-yl]benzoic acid;perchlorate | 2-[2-(4-methylphenyl)-4,6-diphenyl-1-pyridin-1-iumyl]benzoic acid;perchlorate | 2-[2-(4-methylphenyl)-4,6-diphenyl-pyridin-1-ium-1-yl]benzoic acid;perchlorate | 2-[2-(4-methylphenyl)-4,6-diphenylpyridin-1-ium-1-yl]benzoic acid;perchlorate | MLS001240936 | SMR000841332 | cid_12627139

Type

Small organic molecule

Emp. Form.

C31H24NO2

Mol. Mass.

442.5272

SMILES

Cc1ccc(cc1)-c1cc(cc(-c2ccccc2)[n+]1-c1ccccc1C(O)=O)-c1ccccc1 |(.83,9.01,;2.16,9.78,;2.16,11.32,;3.49,12.09,;4.83,11.32,;4.83,9.78,;3.49,9.01,;6.16,12.09,;6.16,13.63,;7.5,14.4,;8.83,13.63,;8.83,12.09,;10.35,12.36,;11.34,11.18,;12.85,11.45,;13.38,12.89,;12.39,14.07,;10.87,13.81,;7.5,11.32,;7.5,9.78,;6.16,9.01,;6.16,7.47,;7.5,6.7,;8.83,7.47,;8.83,9.01,;10.35,8.74,;10.87,7.3,;11.34,9.92,;7.5,15.94,;8.83,16.71,;8.83,18.25,;7.5,19.02,;6.16,18.25,;6.16,16.71,)|

Structure