Ki Summary

Reaction Details

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Target

Methyl-CpG-binding domain protein 2

Ligand

BDBM114646

Substrate/Competitor

n/a

Meas. Tech.

TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide

IC50

15377±n/a nM

Citation

PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay(2013)[AID]

More Info.:

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Methyl-CpG-binding domain protein 2

Name:

Methyl-CpG-binding domain protein 2

Synonyms:

MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

43278.74

Organism:

Homo sapiens (Human)

Description:

gi_21595776

Residue:

411

Sequence:

MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRG
RGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGG
APRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF
SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLN
TTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQII
KTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCK
AFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA

BDBM114646

n/a

Name

BDBM114646

Synonyms:

MLS002702314 | N-[2-(dimethylamino)ethyl]-2-(4-pyridyl)-1H-benzimidazole-4-carboxamide;hydrochloride | N-[2-(dimethylamino)ethyl]-2-pyridin-4-yl-1H-benzimidazole-4-carboxamide;hydrochloride | SMR001565876 | cid_386523

Type

Small organic molecule

Emp. Form.

C17H19N5O

Mol. Mass.

309.3657

SMILES

CN(C)CCNC(=O)c1cccc2nc([nH]c12)-c1ccncc1

Structure