Ki Summary

Reaction Details

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Target

Methyl-CpG-binding domain protein 2

Ligand

BDBM114648

Substrate/Competitor

n/a

Meas. Tech.

TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide

IC50

43749±n/a nM

Citation

PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay(2013)[AID]

More Info.:

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Methyl-CpG-binding domain protein 2

Name:

Methyl-CpG-binding domain protein 2

Synonyms:

MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

43278.74

Organism:

Homo sapiens (Human)

Description:

gi_21595776

Residue:

411

Sequence:

MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRG
RGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGG
APRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF
SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLN
TTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQII
KTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCK
AFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA

BDBM114648

n/a

Name

BDBM114648

Synonyms:

5-(1-butyl-1,2,3,4-tetrazol-5-yl)-1-(3-imidazol-1-ylpropyl)-5-methyl-pyrrolidin-2-one | 5-(1-butyl-5-tetrazolyl)-1-[3-(1-imidazolyl)propyl]-5-methyl-2-pyrrolidinone | 5-(1-butyltetrazol-5-yl)-1-(3-imidazol-1-ylpropyl)-5-methyl-2-pyrrolidone | 5-(1-butyltetrazol-5-yl)-1-(3-imidazol-1-ylpropyl)-5-methylpyrrolidin-2-one | MLS003552197 | SMR002203702 | cid_53300809

Type

Small organic molecule

Emp. Form.

C16H25N7O

Mol. Mass.

331.416

SMILES

CCCCn1nnnc1C1(C)CCC(=O)N1CCCn1ccnc1

Structure