Reaction Details |
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Target | Lysine-specific histone demethylase 1A |
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Ligand | BDBM113755 |
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Substrate/Competitor | n/a |
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Meas. Tech. | GST-LSD1 Enzymatic Assays |
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pH | 7.5±n/a |
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Ki | 1.6e+3± 4.9e+2 nM |
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Comments | extracted |
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Citation | Prusevich, P; Kalin, JH; Ming, SA; Basso, M; Givens, J; Li, X; Hu, J; Taylor, MS; Cieniewicz, AM; Hsiao, PY; Huang, R; Roberson, H; Adejola, N; Avery, LB; Casero, RA; Taverna, SD; Qian, J; Tackett, AJ; Ratan, RR; McDonald, OG; Feinberg, AP; Cole, PA A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1. ACS Chem Biol9:1284-93 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine-specific histone demethylase 1A |
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Name: | Lysine-specific histone demethylase 1A |
Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
Type: | Enzyme |
Mol. Mass.: | 92901.01 |
Organism: | Homo sapiens (Human) |
Description: | O60341 |
Residue: | 852 |
Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
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BDBM113755 |
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n/a |
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Name | BDBM113755 |
Synonyms: | N-Benzyl-N-[4-(2-hydrazinylethyl)phenyl]-4-phenylbutanamide oxalate salt (12m) |
Type | Small organic molecule |
Emp. Form. | C25H29N3O |
Mol. Mass. | 387.5173 |
SMILES | NNCCc1ccc(cc1)N(Cc1ccccc1)C(=O)CCCc1ccccc1 |
Structure |
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