| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF11 [1-973] |
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| Ligand | BDBM115177 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Microtubule-activated ATPase Kinetic Assay |
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| IC50 | 1.37e+3±n/a nM |
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| Citation |  Carbajales, C; Prado, MÁ; Gutirrez-de-Tern, H; Gutiérrez-de-Terán, A; Azuaje, J; Novio, S; Nuez, MJ; Nuñez, B; Fernández-García, E; Garca-Mera, X; García-Mera, P; Sánchez-Lazo, M; Coelho, A Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction. Chembiochem15:1471-80 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIF11 [1-973] |
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| Name: | Kinesin-like protein KIF11 [1-973] |
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| Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin-5 motor protein (KSP) | TRIP5 |
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| Type: | Protein |
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| Mol. Mass.: | 109974.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P52732[1-973] |
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| Residue: | 973 |
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| Sequence: | MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETI
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| BDBM115177 |
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| n/a |
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| Name | BDBM115177 |
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| Synonyms: | (−)-Ethyl 2-[2-(2-benzoyl-5,6-dibromo-1H-benzo[d]imidazol-1-yl)pentanamido]acetate (Compound 23) | (+)-Ethyl 2-[2-(2-benzoyl-5,6-dibromo-1H-benzo[d]imidazol-1-yl)pentanamido] acetate (Compound 22) |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23Br2N3O4 |
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| Mol. Mass. | 565.254 |
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| SMILES | CCCC(C(=O)NCC(=O)OCC)n1c(nc2cc(Br)c(Br)cc12)C(=O)c1ccccc1 |
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| Structure | 
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