| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Ligand | BDBM116309 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Scintillation Proximity Assay |
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| pH | 8±n/a |
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| IC50 | 4.8±n/a nM |
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| Comments | extracted |
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| Citation |  Bergmann, JE; Cutshall, NS; Demopulos, GA; Florio, VA; Gaitanaris, G; Gray, P; Hohmann, J; Onrust, R; Zeng, H Use of PDE7 inhibitors for the treatment of movement disorders US Patent US8637528 Publication Date 1/28/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Type: | Enzyme |
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| Mol. Mass.: | 51842.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NP56 |
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| Residue: | 450 |
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| Sequence: | MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS
GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF
LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD
VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS
VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN
KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS
PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ
HRSRGSSGSGPDHDHAGQGTESEEQEGDSP
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| BDBM116309 |
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| n/a |
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| Name | BDBM116309 |
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| Synonyms: | US8637528, OM69 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N4O2 |
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| Mol. Mass. | 353.4376 |
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| SMILES | COc1cc(N)ccc1-c1cc2c(C(N=[N+]2C)C2CCCCC2)c(=O)[nH]1 |c:15| |
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| Structure | 
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