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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM282936 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.800±n/a nM | ||
| Comments | extracted | ||
| Citation |  Kinsella, T; Gelman, M; Hong, H; Darwish, IS; Singh, R; Yu, J; Borzilleri, RM; Velaparthi, U; Liu, P; Darne, C; Rahaman, H; Warrier, JS TGF-beta inhibitors US Patent US9884868 Publication Date 2/6/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM282936 | |||
| n/a | |||
| Name | BDBM282936 | ||
| Synonyms: | 6-(4-(3-chloro-4-fluorophenyl)-1-(3-fluorocyclobutyl)- 1H-imidazol-5-yl)imidazo[1,2-b]pyridazine-3- carboxamide | US10287295, Example 141' | US11352360, Example 141' | US9884868, Example 141' | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H15ClF2N6O | ||
| Mol. Mass. | 428.823 | ||
| SMILES | NC(=O)c1cnc2ccc(nn12)-c1c(ncn1C1CC(F)C1)-c1ccc(F)c(Cl)c1 |(-6.29,-2.18,;-4.81,-1.78,;-3.72,-2.87,;-4.41,-.29,;-5.31,.96,;-4.41,2.2,;-2.94,1.73,;-1.61,2.5,;-.28,1.73,;-.28,.19,;-1.61,-.58,;-2.94,.19,;1.06,-.58,;2.52,-.11,;3.43,-1.35,;2.52,-2.6,;1.06,-2.12,;-.03,-3.21,;-1.57,-3.21,;-1.57,-4.75,;-2.66,-5.84,;-.03,-4.75,;2.92,1.38,;1.83,2.47,;2.23,3.96,;3.72,4.35,;4.12,5.84,;4.81,3.27,;6.29,3.66,;4.41,1.78,)| | ||
| Structure | 
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