| Reaction Details |
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 | Report a problem with these data |
| Target | Aldehyde dehydrogenase, mitochondrial |
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| Ligand | BDBM118212 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ALDH2 Assay |
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| pH | 7.4±n/a |
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| IC50 | 15±n/a nM |
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| Comments | extracted |
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| Citation |  Graupe, M; Venkataramani, C; Zablocki, J ALDH-2 inhibitors in the treatment of addiction US Patent US8673966 Publication Date 3/18/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldehyde dehydrogenase, mitochondrial |
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| Name: | Aldehyde dehydrogenase, mitochondrial |
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| Synonyms: | ALDH class 2 | ALDH-E2 | ALDH2 | ALDH2_HUMAN | ALDHI | ALDM | Aldehyde dehydrogenase (ALDH2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56382.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05091 |
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| Residue: | 517 |
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| Sequence: | MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
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| BDBM118212 |
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| n/a |
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| Name | BDBM118212 |
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| Synonyms: | US8673966, N-(4-(7-((1,2-dimethyl-1H-imidazol-5- yl)ethynyl)-4-oxo-4H-chromen-3-yl)phenyl)methanesulfonamide |
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| Type | n/a |
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| Emp. Form. | C23H19N3O4S |
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| Mol. Mass. | 433.48 |
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| SMILES | Cc1ncc(C#Cc2ccc3c(c2)occ(-c2ccc(NS(C)(=O)=O)cc2)c3=O)n1C |
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| Structure | 
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