| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldehyde dehydrogenase, mitochondrial |
|---|
| Ligand | BDBM118222 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ALDH2 Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 15±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Graupe, M; Venkataramani, C; Zablocki, J ALDH-2 inhibitors in the treatment of addiction US Patent US8673966 Publication Date 3/18/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldehyde dehydrogenase, mitochondrial |
|---|
| Name: | Aldehyde dehydrogenase, mitochondrial |
|---|
| Synonyms: | ALDH class 2 | ALDH-E2 | ALDH2 | ALDH2_HUMAN | ALDHI | ALDM | Aldehyde dehydrogenase (ALDH2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56382.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05091 |
|---|
| Residue: | 517 |
|---|
| Sequence: | MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
|
|
|
|---|
| BDBM118222 |
|---|
| n/a |
|---|
| Name | BDBM118222 |
|---|
| Synonyms: | US8673966, N-(4-(7-((1-(2-hydroxyacetyl)azetidin-3- yl)ethynyl)-4-oxo-4H-chromen-3-yl)phenyl)methanesulfonamide |
|---|
| Type | n/a |
|---|
| Emp. Form. | C23H20N2O6S |
|---|
| Mol. Mass. | 452.48 |
|---|
| SMILES | CS(=O)(=O)Nc1ccc(cc1)-c1coc2cc(ccc2c1=O)C#CC1CN(C1)C(=O)CO |
|---|
| Structure | 
|
|---|
Search and Browse
