Reaction Details |
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Target | Aldehyde dehydrogenase, mitochondrial |
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Ligand | BDBM118225 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ALDH2 Assay |
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pH | 7.4±n/a |
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IC50 | 6±n/a nM |
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Comments | extracted |
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Citation | Graupe, M; Venkataramani, C; Zablocki, J ALDH-2 inhibitors in the treatment of addiction US Patent US8673966 Publication Date 3/18/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Aldehyde dehydrogenase, mitochondrial |
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Name: | Aldehyde dehydrogenase, mitochondrial |
Synonyms: | ALDH class 2 | ALDH-E2 | ALDH2 | ALDH2_HUMAN | ALDHI | ALDM | Aldehyde dehydrogenase (ALDH2) |
Type: | Enzyme |
Mol. Mass.: | 56382.67 |
Organism: | Homo sapiens (Human) |
Description: | P05091 |
Residue: | 517 |
Sequence: | MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
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BDBM118225 |
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n/a |
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Name | BDBM118225 |
Synonyms: | US8673966, N-(4-(7-((1-(3-methyloxetane-3- carbonyl)azetidin-3-yl)ethynyl)-4-oxo-4H-chromen-3-yl)phenyl)methanesulfonamide |
Type | n/a |
Emp. Form. | C26H24N2O6S |
Mol. Mass. | 492.544 |
SMILES | CC1(COC1)C(=O)N1CC(C1)C#Cc1ccc2c(c1)occ(-c1ccc(NS(C)(=O)=O)cc1)c2=O |
Structure |
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