| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl hydroxylase EGLN2 |
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| Ligand | BDBM118343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 1700±n/a nM |
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| Citation |  Thede, K; Flamme, I; Oehme, F; Ergüden, J; Stoll, F; Schuhmacher, J; Wild, H; Kolkhof, P; Beck, H; Keldenich, J; Akbaba, M; Jeske, M Substituted dihydropyrazolones for treating cardiovascular and hematological diseases US Patent US8653111 Publication Date 2/18/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl hydroxylase EGLN2 |
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| Name: | Prolyl hydroxylase EGLN2 |
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| Synonyms: | EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1) |
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| Type: | Protein |
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| Mol. Mass.: | 43657.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96KS0 |
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| Residue: | 407 |
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| Sequence: | MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
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| BDBM118343 |
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| n/a |
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| Name | BDBM118343 |
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| Synonyms: | US8653111, 101 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13N7O2 |
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| Mol. Mass. | 299.288 |
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| SMILES | OC1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O |
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| Structure | 
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