| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramate--L-alanine ligase |
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| Ligand | BDBM119081 |
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| Substrate/Competitor | n/a |
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| IC50 | 49±0.0 nM |
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| Citation |  Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem55:2-15 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| UDP-N-acetylmuramate--L-alanine ligase |
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| Name: | UDP-N-acetylmuramate--L-alanine ligase |
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| Synonyms: | MURC_ECOLI | MurC (E. coli) | UDP-N-acetylmuramate--L-alanine ligase | murC |
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| Type: | Protein |
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| Mol. Mass.: | 53617.78 |
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| Organism: | Escherichia coli |
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| Description: | P17952 |
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| Residue: | 491 |
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| Sequence: | MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
MNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDA
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAA
VAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVD
ATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGA
DSRSLCRTIRGRGKIDPILVPDPARVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKL
KPQTPEEEQHD
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| BDBM119081 |
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| n/a |
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| Name | BDBM119081 |
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| Synonyms: | MurC inhibitor (compound 20) |
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| Type | Small organic molecule |
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| Emp. Form. | C22H36N3O21P3 |
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| Mol. Mass. | 771.45 |
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| SMILES | CC(CP(O)(=O)CO[C@H]1[C@H](O)[C@@H](CO)OC(OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@@H]1NC(C)=O)C(O)=O |r| |
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| Structure | 
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