| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Ligand | BDBM119103 |
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| Substrate/Competitor | n/a |
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| IC50 | 4.5e+4±n/a nM |
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| Citation |  Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem55:2-15 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Name: | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Synonyms: | D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD |
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| Type: | Ligase |
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| Mol. Mass.: | 46963.02 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | n/a |
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| Residue: | 438 |
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| Sequence: | MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLND
EWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVT
TLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNV
TEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHL
NHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGL
PHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYL
NGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQF
KNFEQRGNEFARLAKELG
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| BDBM119103 |
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| n/a |
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| Name | BDBM119103 |
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| Synonyms: | MurD inhibitor (compound 45) |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N3O6S2 |
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| Mol. Mass. | 499.559 |
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| SMILES | OC(=O)CC[C@@H](NC(=O)c1cccc(CNc2ccc(C=C3SC(S)=NC3=O)cc2)c1)C(O)=O |r,w:20.19,c:24| |
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| Structure | 
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