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TargetApurinic-apyrimidinic endonuclease 1 (APE-1)
LigandBDBM119124
Substrate/Competitorn/a
Meas. Tech.Electrophoretic Mobility Shift Assays (EMSAs)
pH7.5±n/a
IC50 8.5e+3± 0 nM
Commentsextracted
Citation Zhang JLuo MMarasco DLogsdon DLaFavers KAChen QReed AKelley MRGross MLGeorgiadis MM Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited. Biochemistry 52:2955-66 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Apurinic-apyrimidinic endonuclease 1 (APE-1)
Name:Apurinic-apyrimidinic endonuclease 1 (APE-1)
Synonyms:Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase
Type:Protein
Mol. Mass.:35560.12
Organism:Homo sapiens (Human)
Description:P27695
Residue:318
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
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  Blast E-value cutoff:
BDBM119124
n/a
NameBDBM119124
Synonyms:(E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa- 1,4-dien-1-yl)methylene]-N-methoxy-undecanamide | E3330-amide
TypeSmall organic molecule
Emp. Form.C22H33NO6
Mol. Mass.407.5005
SMILESCCCCCCCCCC(=CC1=C(C)C(=O)C(OC)=C(OC)C1=O)C(=O)NOC |w:10.10,c:11,t:18|
Structure
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