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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM119217
Substrate/Competitorn/a
Meas. Tech.Time Resolved Fluorescence Assay
IC50 6±n/a nM
Citation McCoull, WPacker, MScott, JSWhittamore, PR Chemical compounds US Patent US8673938 Publication Date 3/18/2014
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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  Blast E-value cutoff:
BDBM119217
n/a
NameBDBM119217
Synonyms:US8673938, 75
TypeSmall organic molecule
Emp. Form.C24H31N3O3S
Mol. Mass.441.586
SMILESCCSc1nc(ccc1C(=O)NC1C2CC3CC(C2)CC1C3)N1C[C@H]2[C@@H](C1)[C@@H]2C(O)=O |r,wU:24.27,25.29,wD:27.33,TLB:14:15:19:12.13.18,11:12:19:15.16.21,THB:14:13:19:15.16.21,16:15:12:19.17.18,16:17:12:15.14.21,11:12:15.14.21:19.17.18,(5.13,2.12,;3.59,2.12,;3.19,.63,;1.7,.23,;.61,1.32,;-.88,.92,;-1.27,-.56,;-.19,-1.65,;1.3,-1.25,;2.39,-2.34,;1.99,-3.83,;3.88,-1.94,;4.97,-3.03,;6.3,-2.27,;7.63,-3.03,;7.63,-4.57,;6.73,-6.5,;5.53,-5.83,;5.55,-3.43,;4.13,-6.47,;4.97,-4.57,;6.3,-5.35,;-1.97,2.01,;-1.97,3.55,;-3.43,4.03,;-4.33,2.78,;-3.43,1.54,;-4.96,4.19,;-6.29,4.96,;-6.29,6.5,;-7.63,4.19,)|
Structure
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