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Target5-lipoxygenase/FLAP
LigandBDBM283262
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki 0.000±n/a nM
Citation Bacani GMEccles WFitzgerald AEGoldberg SDHack MDHawryluk NAJones WMKeith JMKrawczuk PLebsack ADLee-Dutra ALiu JMcClure KJMeduna SPPippel DJRosen MDSales ZS FLAP modulators US Patent  US9884878 Publication Date 2/6/2018
More Info.:Get all data from this article,  Assay Method
 
5-lipoxygenase/FLAP
Name:5-lipoxygenase/FLAP
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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  Blast E-value cutoff:
BDBM283262
n/a
NameBDBM283262
Synonyms:(S)-(1-{[4'-(5-Aminopyrazin-2-yl)-3'- fluorobiphenyl-2-yl]sulfonyl}-2,3-dihydro-1H- indol-2-yl)methanol | US9745328, Compound 135 | US9884878, Compound 135
TypeSmall organic molecule
Emp. Form.C25H21FN4O3S
Mol. Mass.476.523
SMILESNc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1[C@H](CO)Cc2ccccc12 |r|
Structure
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