Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetArachidonate 5-lipoxygenase-activating protein
LigandBDBM283288
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki<0.1±n/a nM
Citation Bacani, GMEccles, WFitzgerald, AEGoldberg, SDHack, MDHawryluk, NAJones, WMKeith, JMKrawczuk, PLebsack, ADLee-Dutra, ALiu, JMcClure, KJMeduna, SPPippel, DJRosen, MDSales, ZS FLAP modulators US Patent US9884878 Publication Date 2/6/2018
More Info.:Get all data from this article,  Assay Method
 
Arachidonate 5-lipoxygenase-activating protein
Name:Arachidonate 5-lipoxygenase-activating protein
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM283288
n/a
NameBDBM283288
Synonyms:4'-(5-aminopyrazin-2-yl)-3'-fluoro-N-((1R,2S)- 2-hydroxy-2,3-dihydro-1H-inden-1-yl)-[1,1'- biphenyl]-2-sulfonamide | US9745328, Compound 161 | US9884878, Compound 161
TypeSmall organic molecule
Emp. Form.C25H21FN4O3S
Mol. Mass.476.523
SMILESNc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@H]1[C@@H](O)Cc2ccccc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: