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TargetArachidonate 5-lipoxygenase-activating protein
LigandBDBM283335
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki<0.1±n/a nM
Citation Bacani, GMEccles, WFitzgerald, AEGoldberg, SDHack, MDHawryluk, NAJones, WMKeith, JMKrawczuk, PLebsack, ADLee-Dutra, ALiu, JMcClure, KJMeduna, SPPippel, DJRosen, MDSales, ZS FLAP modulators US Patent US9884878 Publication Date 2/6/2018
More Info.:Get all data from this article,  Assay Method
 
Arachidonate 5-lipoxygenase-activating protein
Name:Arachidonate 5-lipoxygenase-activating protein
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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  Blast E-value cutoff:
BDBM283335
n/a
NameBDBM283335
Synonyms:4'-(5-Aminopyrazxin-2-yl)-3'-fluoro-N-methyl-4- (trifluoromethyl)biphenyl-2-sulfonamide | US9745328, Compound 208 | US9884878, Compound 208
TypeSmall organic molecule
Emp. Form.C18H14F4N4O2S
Mol. Mass.426.388
SMILESCNS(=O)(=O)c1cc(ccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F
Structure
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