Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetArachidonate 5-lipoxygenase-activating protein
LigandBDBM283502
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki<0.1±n/a nM
Citation Bacani, GMEccles, WFitzgerald, AEGoldberg, SDHack, MDHawryluk, NAJones, WMKeith, JMKrawczuk, PLebsack, ADLee-Dutra, ALiu, JMcClure, KJMeduna, SPPippel, DJRosen, MDSales, ZS FLAP modulators US Patent US9884878 Publication Date 2/6/2018
More Info.:Get all data from this article,  Assay Method
 
Arachidonate 5-lipoxygenase-activating protein
Name:Arachidonate 5-lipoxygenase-activating protein
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM283502
n/a
NameBDBM283502
Synonyms:3'-Fluoro-4'-(5H-pyrrolo[2,3-b]pyrazin-2-yl)N-- N-(2,2,2-trifluoro-1-methylethyl)biphenyl-2- sulfonamide | US9745328, Compound 376 | US9884878, Compound 376
TypeSmall organic molecule
Emp. Form.C21H16F4N4O2S
Mol. Mass.464.436
SMILESCC(NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2n1)C(F)(F)F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: