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TargetArachidonate 5-lipoxygenase-activating protein
LigandBDBM283677
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki<0.1±n/a nM
Citation Bacani, GMEccles, WFitzgerald, AEGoldberg, SDHack, MDHawryluk, NAJones, WMKeith, JMKrawczuk, PLebsack, ADLee-Dutra, ALiu, JMcClure, KJMeduna, SPPippel, DJRosen, MDSales, ZS FLAP modulators US Patent US9884878 Publication Date 2/6/2018
More Info.:Get all data from this article,  Assay Method
 
Arachidonate 5-lipoxygenase-activating protein
Name:Arachidonate 5-lipoxygenase-activating protein
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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  Blast E-value cutoff:
BDBM283677
n/a
NameBDBM283677
Synonyms:5-[3-Fluoro-2'-(pyrimidin-2-yloxy)-4'- (trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine | US9745328, Compound 551 | US9884878, Compound 551
TypeSmall organic molecule
Emp. Form.C21H13F4N5O
Mol. Mass.427.3544
SMILESNc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1Oc1ncccn1)C(F)(F)F
Structure
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