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TargetDNA primase (Ba DnaG)
LigandBDBM22984
Substrate/Competitorn/a
Meas. Tech.Quatitative Inhibition Analysis Assay
pH8.8±n/a
IC50 4.4e+3± 3e+2 nM
Commentsextracted
Citation Biswas TGreen KDGarneau-Tsodikova STsodikov OV Discovery of inhibitors of Bacillus anthracis primase DnaG. Biochemistry 52:6905-10 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA primase (Ba DnaG)
Name:DNA primase (Ba DnaG)
Synonyms:n/a
Type:Protein
Mol. Mass.:68258.37
Organism:Bacillus anthracis (Firmicutes)
Description:Q81LU4
Residue:598
Sequence:
MGNRIPEEVVEQIRTSSDIVEVIGEYVQLRKQGRNYFGLCPFHGENSPSFSVSSDKQIFH
CFGCGEGGNVFSFLMKMEGLAFTEAVQKLGERNGIAVAEYTSGQGQQEDISDDTVIMQQA
HELLKKYYHHLLVNTEEGNEALSYLLKRGITKEMIEKFEIGYASPAWDAATKILQKRGLS
LSSMEQAGLLIRSEKDGSHYDRFRGRVMFPIYTLQGKVIAFSGRALGDDTPKYLNSPETP
IFHKSKLLYNFHQARPFIRKRGQVVLFEGYADVLAAVKSGVEEAVATMGTALTEEQAKLL
RRNVETVVLCYDGDKAGREATMKAGQLLLQVGCQVKVTSLPDKLDPDEYVQQYGTTAFEN
LVKSSISFVGFKINYLRLGKNLQDESGKEEYVKSVLKELSLLQDAMQAESYLKSLSQEFS
YSMETLLNQLHQYRKEQKVQQKQVKQVSKPSQIVQTKPKLTGFERAEREIIYHMLQSPEV
AVRMESHIEDFHTEEHKGILYELYAYYEKGNEPSVGTFLSWLSDEKLKNIITDISTDEFI
NPEYTEEVLQSHLETLRRHQEKLEKMEIIFKIKQMEKTDPVEAAKYYVAYLQNQKARK
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  Blast E-value cutoff:
BDBM22984
n/a
NameBDBM22984
Synonyms:(8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione | Adriamycin | Adriblastina | CHEMBL53463 | Doxil | Doxorubicin
TypeAntibiotic
Emp. Form.C27H29NO11
Mol. Mass.543.5193
SMILESCOc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO |r|
Structure
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