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TargetEnoyl-acyl carrier reductase
LigandBDBM119868
Substrate/Competitorn/a
Meas. Tech.TgENR Inhibition Assay
pH7.5±n/a
IC50 43±0.0 nM
Commentsextracted
Citation Afanador GAMuench SPMcPhillie MFomovska ASchön ASchön YCheng GStec JFreundlich JSShieh HMAnderson JWJacobus DPFidock DAKozikowski APFishwick CWRice DWFreire EMcLeod RPrigge ST Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry 52:9155-66 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Enoyl-acyl carrier reductase
Name:Enoyl-acyl carrier reductase
Synonyms:Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative
Type:PROTEIN
Mol. Mass.:43663.67
Organism:Toxoplasma gondii
Description:ChEMBL_1290812
Residue:417
Sequence:
MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSS
SSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVA
DSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYP
LDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPL
LETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKA
ALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLR
RDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM119868
n/a
NameBDBM119868
Synonyms:2‐{4‐[(4‐butyl‐1,2,3‐triazol‐1‐yl)methyl]‐2‐ chlorophenoxy}‐5‐chlorophenol (25)
TypeSmall organic molecule
Emp. Form.C19H19Cl2N3O2
Mol. Mass.392.279
SMILESCCCCc1cn(Cc2ccc(Oc3ccc(Cl)cc3O)c(Cl)c2)nn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: