| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-acyl carrier reductase ENR |
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| Ligand | BDBM119871 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TgENR Inhibition Assay |
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| pH | 7.5±n/a |
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| IC50 | 100±0.0 nM |
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| Comments | extracted |
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| Citation |  Afanador, GA; Muench, SP; McPhillie, M; Fomovska, A; Schön, A; Schön, Y; Cheng, G; Stec, J; Freundlich, JS; Shieh, HM; Anderson, JW; Jacobus, DP; Fidock, DA; Kozikowski, AP; Fishwick, CW; Rice, DW; Freire, E; McLeod, R; Prigge, ST Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry52:9155-66 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-acyl carrier reductase ENR |
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| Name: | Enoyl-acyl carrier reductase ENR |
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| Synonyms: | Enoyl-acyl carrier reductase | Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43663.67 |
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| Organism: | Toxoplasma gondii |
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| Description: | ChEMBL_1290812 |
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| Residue: | 417 |
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| Sequence: | MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSS
SSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVA
DSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYP
LDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPL
LETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKA
ALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLR
RDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
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| BDBM119871 |
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| n/a |
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| Name | BDBM119871 |
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| Synonyms: | N‐{[3‐chloro‐4‐(4‐chloro‐2‐ hydroxyphenoxy)phenyl]methyl}‐5‐methyl‐1,2‐oxazole‐3‐ carboxamide (29) |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14Cl2N2O4 |
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| Mol. Mass. | 393.221 |
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| SMILES | Cc1cc(no1)C(=O)NCc1ccc(Oc2ccc(Cl)cc2O)c(Cl)c1 |
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| Structure | 
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