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TargetEnoyl-acyl carrier reductase
LigandBDBM50431920
Substrate/Competitorn/a
Meas. Tech.TgENR Inhibition Assay
pH7.5±n/a
IC50 58±0.0 nM
Commentsextracted
Citation Afanador GAMuench SPMcPhillie MFomovska ASchön ASchön YCheng GStec JFreundlich JSShieh HMAnderson JWJacobus DPFidock DAKozikowski APFishwick CWRice DWFreire EMcLeod RPrigge ST Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry 52:9155-66 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Enoyl-acyl carrier reductase
Name:Enoyl-acyl carrier reductase
Synonyms:Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative
Type:PROTEIN
Mol. Mass.:43663.67
Organism:Toxoplasma gondii
Description:ChEMBL_1290812
Residue:417
Sequence:
MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSS
SSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVA
DSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYP
LDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPL
LETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKA
ALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLR
RDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50431920
n/a
NameBDBM50431920
Synonyms:5‐(4‐chloro‐2‐hydroxyphenoxy)‐N‐(5‐methyl‐1,2‐ oxazol‐3‐yl)furan‐2‐carboxamide (32) | CHEMBL2347835
TypeSmall organic molecule
Emp. Form.C15H11ClN2O5
Mol. Mass.334.711
SMILESCc1cc(NC(=O)c2ccc(Oc3ccc(Cl)cc3O)o2)no1
Structure
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