| Reaction Details |
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 | Report a problem with these data |
| Target | Myeloperoxidase |
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| Ligand | BDBM119874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MPO Activity Assay |
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| pH | 7.4±n/a |
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| Ki | 429±120 nM |
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| Comments | extracted |
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| Citation |  Ward, J; Spath, SN; Pabst, B; Carpino, PA; Ruggeri, RB; Xing, G; Speers, AE; Cravatt, BF; Ahn, K Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling. Biochemistry52:9187-201 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Myeloperoxidase |
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| Name: | Myeloperoxidase |
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| Synonyms: | 84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | Mpo protein | Myeloperoxidase | Myeloperoxidase (MPO) | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 83888.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05164 |
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| Residue: | 745 |
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| Sequence: | MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS
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| BDBM119874 |
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| n/a |
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| Name | BDBM119874 |
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| Synonyms: | 3‐[(2S)‐2‐ethoxypropyl]‐2‐sulfanylidene‐1,9‐ dihydropurin‐6‐one (D) |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14N4O2S |
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| Mol. Mass. | 254.309 |
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| SMILES | CCO[C@@H](C)Cn1c2nc[nH]c2c(=O)[nH]c1=S |r| |
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| Structure | 
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