| Reaction Details |
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 | Report a problem with these data |
| Target | N-lysine methyltransferase SMYD2 |
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| Ligand | BDBM283195 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Scintillation Proximity Assay (SPA) for Detection of SMYD2 Enzymatic Inhibition |
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| pH | 9±n/a |
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| IC50 | 15.8±n/a nM |
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| Comments | extracted |
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| Citation |  Mowat, JS; Stellfeld, T; Stresemann, C; Hillig, R; Köhr, S; Stöckigt, D; Weiske, J; Brumby, T; Barak, N; Christ, C; Ter Laak, A; Badock, V; Crampton, RH; Stefanuti, I Aryl-cyanoguanidine compounds US Patent US10023539 Publication Date 7/17/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| N-lysine methyltransferase SMYD2 |
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| Name: | N-lysine methyltransferase SMYD2 |
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| Synonyms: | HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 49689.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NRG4 |
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| Residue: | 433 |
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| Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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| BDBM283195 |
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| n/a |
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| Name | BDBM283195 |
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| Synonyms: | Rac-N-[r-(N′-cyano-N-[2-[2-(pyrrolidin-1-yl)ethoxy]-5-(trifluormethyl)phenyl]carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide | US10023539, Example 30 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30Cl2F3N7O3 |
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| Mol. Mass. | 640.484 |
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| SMILES | CCN(C1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cc(ccc1OCCN1CCCC1)C(F)(F)F)=N/C#N)C(=O)CO |w:3.2,c:6| |
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| Structure | 
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