| Reaction Details |
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 | Report a problem with these data |
| Target | Prephenate dehydrogenase |
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| Ligand | BDBM119877 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assays |
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| Ki | 155±12 nM |
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| Citation |  Bryk, R; Arango, N; Maksymiuk, C; Balakrishnan, A; Wu, YT; Wong, CH; Masquelin, T; Hipskind, P; Lima, CD; Nathan, C Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry52:9375-84 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prephenate dehydrogenase |
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| Name: | Prephenate dehydrogenase |
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| Synonyms: | Prephenate dehydrogenase TyrA (PDH) | TYRA_MYCTU | tyrA |
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| Type: | Protein |
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| Mol. Mass.: | 33096.86 |
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| Organism: | Mycobacterium tuberculosis H37Rv |
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| Description: | O69721 |
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| Residue: | 323 |
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| Sequence: | MTRTVAAPPVCVLGLGLIGGSIMRAAAAAGREVFGYNRSVEGAHGARSDGFDAITDLNQT
LTRAAATEALIVLAVPMPALPGMLAHIRKSAPGCPLTDVTSVKCAVLDEVTAAGLQARYV
GGHPMTGTAHSGWTAGHGGLFNRAPWVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDE
HDAAAAAVSHLPHLLAEALAVTAAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTG
QLAPAADRIIDLLSRARDSLQSHGSIADLADAGHAARTRYDSFPRSDIVTVVIGADKWRE
QLAAAGRAGGVITSALPSLDSPQ
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| BDBM119877 |
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| n/a |
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| Name | BDBM119877 |
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| Synonyms: | SL809 | US9073941, 502 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19BrN4O5S |
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| Mol. Mass. | 459.315 |
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| SMILES | COc1ccc(NC(=O)CN(C)S(=O)(=O)c2cc(Br)cnc2N)cc1OC |
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| Structure | 
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