Reaction Details | |||
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Target | Acetylcholinesterase | ||
Ligand | BDBM50241461 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Assay of Substrate Hydrolysis | ||
pH | 7±n/a | ||
Temperature | 298.15±n/a K | ||
Ki | 110±0.0 nM | ||
Comments | P-site specific extracted | ||
Citation | Beri, V; Wildman, SA; Shiomi, K; Al-Rashid, ZF; Cheung, J; Rosenberry, TL The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity. Biochemistry52:7486-99 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Acetylcholinesterase | |||
Name: | Acetylcholinesterase | ||
Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) | ||
Type: | Enzyme | ||
Mol. Mass.: | 67792.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P22303 | ||
Residue: | 614 | ||
Sequence: |
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BDBM50241461 | |||
n/a | |||
Name | BDBM50241461 | ||
Synonyms: | 3,7-bis(dimethylamino)phenothiazin-5-ium chloride | Basic Blue 9 | CHEMBL405110 | Methylenblau | Methylene Blue anhydrous | Methylene blue | Methylene blue (10) | SAMPL5, CBC-G10 | azul de metileno | bleu de methylene | cid_6099 | methylthioninium chloride | ||
Type | Small organic molecule | ||
Emp. Form. | C16H18N3S | ||
Mol. Mass. | 284.399 | ||
SMILES | CN(C)c1ccc2nc3ccc(cc3sc2c1)=[N+](C)C |(17.73,-40.24,;19.06,-41.01,;19.06,-42.55,;20.39,-40.24,;20.4,-38.7,;21.73,-37.93,;23.06,-38.69,;24.39,-37.91,;25.73,-38.69,;27.06,-37.93,;28.39,-38.69,;28.39,-40.23,;27.06,-41,;25.73,-40.23,;24.39,-41.01,;23.06,-40.24,;21.73,-41.01,;29.73,-41,;29.73,-42.54,;31.06,-40.23,)| | ||
Structure |