| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM92606 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assays |
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| IC50 | 40±n/a nM |
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| Citation |  Bastos, C; Booker, ML; Celatka, CA; Clardy, JC; Cortese, J; Patel, VP; Skerlj, R; Wiegand, RC; Wirth, DF Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase US Patent US8703811 Publication Date 4/22/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial, putative |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62972.27 |
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| Organism: | Plasmodium vivax |
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| Description: | A5K1N1 |
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| Residue: | 572 |
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| Sequence: | MLRHSCLREKGNLIGGSLLRGISAQLRAAGGGTFRSFHSYRSFCSFCIFRRANKADANWY
GCFPGHVAGGATCGPLRGDCAERHKLMAHVRRFSGESTRAKGGDKREGDIEGNRTNGSDK
TKQLEEEMKKLNEQIAREKGNHKKALLFIFTCVVALYMYFESYDPEFFLYDVFLKMLLKY
VDGETCHELFLLMGKYKLLPYDTGKDNIYSCSEIKGLNFINPFGVAAGFDKNGVCIDGIL
KLGFSFIEIGTITPKAQKGNERPRIFRDLETRSIINSCGFNNMGCDEVCKNLKRFRERQK
TDKLLQRHLVGVSLGKNKDSPDILQDLSYCIGKIGRYADYIAINVSSPNTPGLRDHQKGE
RLHGIIQRVKEEVAKLDGGGAPLGGATTGGAAMGGATTGEAVVGKAPPDEAATGGEPWAN
TTKRRPLIFVKLAPDLEEGERKSIANVLLNAEVDGMIICNTTTQKFNIKSFEDKKGGVSG
EKLKGVSTHMISQMYNYTNGKIPIIASGGIFTGEDALEKIEAGASVCQLYSCLVFNGMKA
AVRIKRELDHLLYQRGYYKLGDAVGRAHRRAA
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| BDBM92606 |
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| n/a |
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| Name | BDBM92606 |
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| Synonyms: | DHOD Inhibitor, 5 | US8703811, 6 |
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| Type | Small molecule |
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| Emp. Form. | C18H23NO3 |
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| Mol. Mass. | 301.3801 |
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| SMILES | CCOC(=O)c1[nH]c(C)c(Cc2ccc(OCC)cc2)c1C |
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| Structure | 
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