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TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM120317
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assays
IC50 36±n/a nM
Citation Bastos, CBooker, MLCelatka, CAClardy, JCCortese, JPatel, VPSkerlj, RWiegand, RCWirth, DF Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase US Patent US8703811 Publication Date 4/22/2014
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase
Type:Enzyme
Mol. Mass.:65581.88
Organism:Plasmodium falciparum
Description:His6-tag DHODH was expressed in E. coli.
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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BDBM120317
n/a
NameBDBM120317
Synonyms:US8703811, 58
TypeSmall organic molecule
Emp. Form.C17H14F3N3O2S
Mol. Mass.381.372
SMILESCc1nc2ccc(OC(F)(F)F)cc2n1-c1ccc(s1)C(=O)NC1CC1
Structure
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