| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 8 [1-363] |
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| Ligand | BDBM103302 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Selectivity screening |
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| IC50 | 1080±0.0 nM |
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| Citation |  Chaikuad, A; Tacconi, EM; Zimmer, J; Liang, Y; Gray, NS; Tarsounas, M; Knapp, S A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics Nat Chem Biol10:853-860 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 8 [1-363] |
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| Name: | Mitogen-activated protein kinase 8 [1-363] |
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| Synonyms: | JNK1 | MAPK8 | MK08_HUMAN | PRKM8 | SAPK1 | SAPK1C | c-Jun N-terminal kinase 1 truncation (JNK1) (aa 1-363) |
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| Type: | Protein |
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| Mol. Mass.: | 41916.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK1 truncation 1-363aa (curated by PDB 4QTD) |
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| Residue: | 363 |
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| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDL
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| BDBM103302 |
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| n/a |
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| Name | BDBM103302 |
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| Synonyms: | SCH772984 | US8546404, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H33N9O2 |
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| Mol. Mass. | 587.6742 |
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| SMILES | O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r| |
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| Structure | 
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