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TargetUDP-N-acetylmuramate--L-alanine ligase
LigandBDBM123110
Substrate/Competitorn/a
Meas. Tech.P. aeruginosa MurC assay
Temperature298.15±0 K
IC50 13±n/a nM
Citation Hameed P, SManjrekar, PChinnapattu, MHumnabadkar, VShanbhag, GKedari, CMudugal, NVAmbady, Ade Jonge, BLSadler, CPaul, BSriram, SKaur, PGuptha, SRaichurkar, AFleming, PEyermann, CJMcKinney, DCSambandamurthy, VKPanda, MRavishankar, S Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli. ACS Chem Biol9:2274-82 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-N-acetylmuramate--L-alanine ligase
Name:UDP-N-acetylmuramate--L-alanine ligase
Synonyms:MURC_PSEAE | MurC (P. aeruginosa) | murC
Type:Protein
Mol. Mass.:51977.96
Organism:Pseudomonas aeruginosa (G-proteobacteria)
Description:Q9HW02
Residue:480
Sequence:
MVKEPNGVTRTMRRIRRIHFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFG
AQIFIGHQAENADGADVLVVSSAINRANPEVASALERRIPVVPRAEMLAELMRYRHGIAV
AGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGASRYLVAEADESDASFLH
LQPMVAVVTNIDADHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCVDDPVVREILPQIA
RPTVTYGLSEDADVRAINIRQEGMRTWFTVLRPEREPLDVSVNMPGLHNVLNSLATIVIA
TDEGISDEAIVQGLSGFQGVGRRFQVYGELQVEGGSVMLVDDYGHHPREVAAVIKAIRGG
WPERRLVMVYQPHRYTRTRDLYEDFVQVLGEANVLLLMEVYPAGEEPIPGADSRQLCHSI
RQRGQLDPIYFERDADLAPLVKPLLRAGDILLCQGAGDVGGLAPQLIKNPLFAGKGGKGA
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  Blast E-value cutoff:
BDBM123110
n/a
NameBDBM123110
Synonyms:(R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-3-methylbutan-1-ol (9)
TypeSmall organic molecule
Emp. Form.C18H28N8O
Mol. Mass.372.4679
SMILESCC(C)[C@H](CO)Nc1nc(Nc2cc(n(C)n2)C(C)(C)C)c2c[nH]nc2n1
Structure
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