| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramate--L-alanine ligase |
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| Ligand | BDBM123125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | P. aeruginosa MurC assay |
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| Temperature | 298.15±0 K |
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| IC50 | <0.5±n/a nM |
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| Citation |  Hameed P, S; Manjrekar, P; Chinnapattu, M; Humnabadkar, V; Shanbhag, G; Kedari, C; Mudugal, NV; Ambady, A; de Jonge, BL; Sadler, C; Paul, B; Sriram, S; Kaur, P; Guptha, S; Raichurkar, A; Fleming, P; Eyermann, CJ; McKinney, DC; Sambandamurthy, VK; Panda, M; Ravishankar, S Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli. ACS Chem Biol9:2274-82 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylmuramate--L-alanine ligase |
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| Name: | UDP-N-acetylmuramate--L-alanine ligase |
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| Synonyms: | MURC_PSEAE | MurC (P. aeruginosa) | murC |
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| Type: | Protein |
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| Mol. Mass.: | 51977.96 |
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| Organism: | Pseudomonas aeruginosa (G-proteobacteria) |
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| Description: | Q9HW02 |
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| Residue: | 480 |
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| Sequence: | MVKEPNGVTRTMRRIRRIHFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFG
AQIFIGHQAENADGADVLVVSSAINRANPEVASALERRIPVVPRAEMLAELMRYRHGIAV
AGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGASRYLVAEADESDASFLH
LQPMVAVVTNIDADHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCVDDPVVREILPQIA
RPTVTYGLSEDADVRAINIRQEGMRTWFTVLRPEREPLDVSVNMPGLHNVLNSLATIVIA
TDEGISDEAIVQGLSGFQGVGRRFQVYGELQVEGGSVMLVDDYGHHPREVAAVIKAIRGG
WPERRLVMVYQPHRYTRTRDLYEDFVQVLGEANVLLLMEVYPAGEEPIPGADSRQLCHSI
RQRGQLDPIYFERDADLAPLVKPLLRAGDILLCQGAGDVGGLAPQLIKNPLFAGKGGKGA
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| BDBM123125 |
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| n/a |
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| Name | BDBM123125 |
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| Synonyms: | (R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-2-phenylethyl ((S)-3-methyl-2-oxoimidazolidin-4-yl)methylcarbamate (24) |
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| Type | Small organic molecule |
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| Emp. Form. | C27H35N11O3 |
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| Mol. Mass. | 561.6387 |
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| SMILES | CN1[C@H](CNC(=O)OC[C@H](Nc2nc(Nc3cc(n(C)n3)C(C)(C)C)c3c[nH]nc3n2)c2ccccc2)CNC1=O |
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| Structure | 
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