Reaction Details |
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Target | UDP-N-acetylmuramate--L-alanine ligase |
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Ligand | BDBM123126 |
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Substrate/Competitor | n/a |
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Meas. Tech. | P. aeruginosa MurC assay |
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Temperature | 298.15±0 K |
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IC50 | 7±n/a nM |
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Citation | Hameed P, S; Manjrekar, P; Chinnapattu, M; Humnabadkar, V; Shanbhag, G; Kedari, C; Mudugal, NV; Ambady, A; de Jonge, BL; Sadler, C; Paul, B; Sriram, S; Kaur, P; Guptha, S; Raichurkar, A; Fleming, P; Eyermann, CJ; McKinney, DC; Sambandamurthy, VK; Panda, M; Ravishankar, S Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli. ACS Chem Biol9:2274-82 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-N-acetylmuramate--L-alanine ligase |
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Name: | UDP-N-acetylmuramate--L-alanine ligase |
Synonyms: | MURC_PSEAE | MurC (P. aeruginosa) | murC |
Type: | Protein |
Mol. Mass.: | 51977.96 |
Organism: | Pseudomonas aeruginosa (G-proteobacteria) |
Description: | Q9HW02 |
Residue: | 480 |
Sequence: | MVKEPNGVTRTMRRIRRIHFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFG
AQIFIGHQAENADGADVLVVSSAINRANPEVASALERRIPVVPRAEMLAELMRYRHGIAV
AGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGASRYLVAEADESDASFLH
LQPMVAVVTNIDADHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCVDDPVVREILPQIA
RPTVTYGLSEDADVRAINIRQEGMRTWFTVLRPEREPLDVSVNMPGLHNVLNSLATIVIA
TDEGISDEAIVQGLSGFQGVGRRFQVYGELQVEGGSVMLVDDYGHHPREVAAVIKAIRGG
WPERRLVMVYQPHRYTRTRDLYEDFVQVLGEANVLLLMEVYPAGEEPIPGADSRQLCHSI
RQRGQLDPIYFERDADLAPLVKPLLRAGDILLCQGAGDVGGLAPQLIKNPLFAGKGGKGA
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BDBM123126 |
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n/a |
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Name | BDBM123126 |
Synonyms: | (R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-2-phenylethyl 2-(3-oxopyrazolidin-1-yl)ethylcarbamate (25) |
Type | Small organic molecule |
Emp. Form. | C27H35N11O3 |
Mol. Mass. | 561.6387 |
SMILES | Cn1nc(Nc2nc(N[C@@H](COC(=O)NCCN3CCC(=O)N3)c3ccccc3)nc3n[nH]cc23)cc1C(C)(C)C |
Structure |
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