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TargetUDP-N-acetylmuramate--L-alanine ligase
LigandBDBM123113
Substrate/Competitorn/a
Meas. Tech.E.coli MurC assay
Temperature298.15±0 K
IC50 60±n/a nM
Citation Hameed P, SManjrekar, PChinnapattu, MHumnabadkar, VShanbhag, GKedari, CMudugal, NVAmbady, Ade Jonge, BLSadler, CPaul, BSriram, SKaur, PGuptha, SRaichurkar, AFleming, PEyermann, CJMcKinney, DCSambandamurthy, VKPanda, MRavishankar, S Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli. ACS Chem Biol9:2274-82 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-N-acetylmuramate--L-alanine ligase
Name:UDP-N-acetylmuramate--L-alanine ligase
Synonyms:MURC_ECOLI | MurC (E. coli) | UDP-N-acetylmuramate--L-alanine ligase | murC
Type:Protein
Mol. Mass.:53617.78
Organism:Escherichia coli
Description:P17952
Residue:491
Sequence:
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
MNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDA
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAA
VAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVD
ATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGA
DSRSLCRTIRGRGKIDPILVPDPARVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKL
KPQTPEEEQHD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM123113
n/a
NameBDBM123113
Synonyms:(S)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-2-(3-methylisoxazol-5-yl)ethanol (12)
TypeSmall organic molecule
Emp. Form.C19H25N9O2
Mol. Mass.411.4609
SMILESCc1cc(on1)[C@H](CO)Nc1nc(Nc2cc(n(C)n2)C(C)(C)C)c2c[nH]nc2n1
Structure
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