Ki Summary

Reaction Details

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Target

G-protein coupled receptor 4

Ligand

BDBM123511

Substrate/Competitor

n/a

Meas. Tech.

Radio Ligand Binding Assay

8±n/a

IC50

5±n/a nM

Citation

Miltz, W; Oberhauser, B; Vaupel, A; Velcicky, J; Weigand, K; Leleti, RR; Liu, Y; Du, Z Pyrazolo pyrimidine derivatives US Patent US8748435 Publication Date 6/10/2014

More Info.:

Get all data from this article, Solution Info, Assay Method

G-protein coupled receptor 4

Name:

G-protein coupled receptor 4

Synonyms:

G-protein coupled receptor 4 | G-protein coupled receptor 4 (GPR4) | GPR4 | GPR4_HUMAN

Type:

Enzyme

Mol. Mass.:

40994.40

Organism:

Homo sapiens (Human)

Description:

P46093

Residue:

362

Sequence:

MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLS
IADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVA
HPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAW
MNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPY
HVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKA
LHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPP
AQ

BDBM123511

n/a

Name

BDBM123511

Synonyms:

US8748435, 36

Type

Small organic molecule

Emp. Form.

C25H30N6O

Mol. Mass.

430.5453

SMILES

CCc1nn2c(C)cc(C)nc2c1Cc1ccc(cc1)-c1nnc(o1)[C@H]1CC[C@H](N)CC1 |r,wU:25.28,wD:28.32,(-6.74,4.11,;-7.83,3.02,;-7.43,1.53,;-8.33,.29,;-7.43,-.96,;-7.75,-2.47,;-9.24,-2.86,;-6.6,-3.5,;-5.14,-3.02,;-4.05,-4.11,;-4.82,-1.51,;-5.96,-.48,;-5.96,1.06,;-4.63,1.83,;-3.3,1.06,;-3.3,-.48,;-1.96,-1.25,;-.63,-.48,;-.63,1.06,;-1.96,1.83,;.71,-1.25,;.71,-2.79,;2.17,-3.27,;3.08,-2.02,;2.17,-.78,;4.62,-2.02,;5.39,-.69,;6.93,-.69,;7.7,-2.02,;9.24,-2.02,;6.93,-3.36,;5.39,-3.36,)|

Structure