| Reaction Details |
|---|
 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Ligand | BDBM123687 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Inhibition Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 110±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Hendrix, M; Böβ, F; Burkhardt, N; Erb, C; Tersteegen, A; Van Kampen, M Alkyl-substituted pyrazolopyrimidines US Patent US8741907 Publication Date 6/3/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68488.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O76083 |
|---|
| Residue: | 593 |
|---|
| Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
|
|
|
|---|
| BDBM123687 |
|---|
| n/a |
|---|
| Name | BDBM123687 |
|---|
| Synonyms: | US8741907, 3 | US9067945, 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H26N4O |
|---|
| Mol. Mass. | 302.4145 |
|---|
| SMILES | CCC(CC)n1ncc2c1nc(CC1CCCCC1)[nH]c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
