| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Ligand | BDBM123689 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibition Assay |
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| pH | 7.5±n/a |
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| IC50 | 6±n/a nM |
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| Comments | extracted |
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| Citation |  Hendrix, M; Böβ, F; Burkhardt, N; Erb, C; Tersteegen, A; Van Kampen, M Alkyl-substituted pyrazolopyrimidines US Patent US8741907 Publication Date 6/3/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
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| Type: | Protein |
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| Mol. Mass.: | 68488.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O76083 |
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| Residue: | 593 |
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| Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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| BDBM123689 |
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| n/a |
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| Name | BDBM123689 |
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| Synonyms: | US8741907, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20N4O |
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| Mol. Mass. | 284.3562 |
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| SMILES | O=c1[nH]c(CC2CCC=C2)nc2n(ncc12)C1CCCC1 |c:8| |
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| Structure | 
|
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