| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase D2 |
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| Ligand | BDBM123747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PLD In Vitro Kinetic Assay |
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| Temperature | 310.15±0 K |
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| IC50 | 290±n/a nM |
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| Citation |  Kulkarni, A; Quang, P; Curry, V; Keyes, R; Zhou, W; Cho, H; Baffoe, J; Torok, B; Stieglitz, K 1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D. Chem Biol Drug Des84:270-81 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipase D2 |
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| Name: | Phospholipase D2 |
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| Synonyms: | PLD2 | PLD2_HUMAN | Phospholipase D2 | Phospholipase D2 (PLD2) | phospholipase D2 isoform PLD2A |
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| Type: | Protein |
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| Mol. Mass.: | 106002.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 933 |
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| Sequence: | MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFA
PGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVL
MSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYR
NYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVV
KDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQAR
WWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIF
ITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRAL
MLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSE
SAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPW
RDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQ
CTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDE
IVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHR
LKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLL
GKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICD
DFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQ
GHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
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| BDBM123747 |
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| n/a |
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| Name | BDBM123747 |
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| Synonyms: | 1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (5) | 1-tert-butyl-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (5) | CHEMBL2069938 | US10544104, Compound 140 | US9765037, Compound 140 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N5 |
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| Mol. Mass. | 267.329 |
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| SMILES | CC(C)(C)n1nc(-c2ccccc2)c2c(N)ncnc12 |
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| Structure | 
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