| Reaction Details |
|---|
 | Report a problem with these data |
| Target | G protein-coupled receptor kinase 5 |
|---|
| Ligand | BDBM50173315 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Assays for Inhibition of GRKs |
|---|
| pH | 7±n/a |
|---|
| IC50 | 800±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Larsen, SD; Homan, K; Waldschmidt, H; Tesmer, JJ G protein-coupled receptor kinase 2 inhibitors and methods for use of the same US Patent US10023564 Publication Date 7/17/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| G protein-coupled receptor kinase 5 |
|---|
| Name: | G protein-coupled receptor kinase 5 |
|---|
| Synonyms: | G protein-coupled receptor kinase GRK5 | GPRK5 | GRK5 | GRK5_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 67798.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1280627 |
|---|
| Residue: | 590 |
|---|
| Sequence: | MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ
PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ
VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN
HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
|
|
|
|---|
| BDBM50173315 |
|---|
| n/a |
|---|
| Name | BDBM50173315 |
|---|
| Synonyms: | CHEMBL3809100 | US10023564, Example 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H22F2N6O3 |
|---|
| Mol. Mass. | 516.4988 |
|---|
| SMILES | CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1cccc(F)c1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
