| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein |
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| Ligand | BDBM124110 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic assay |
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| pH | 7.5±n/a |
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| Temperature | 303.15±n/a K |
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| Ki | 43±n/a nM |
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| Comments | extracted |
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| Citation |  Simmen, KA; De Kock, HA; Rabiosson, PJ; Tahri, A; Nilsson, KM; Samuelsson, BB; Rosenquist, AA; Antonov, D Macrocyclic inhibitors of hepatitis C virus US Patent US8754105 Publication Date 6/17/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein |
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| Name: | Genome polyprotein |
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| Synonyms: | NS3/4A protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 73007.91 |
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| Organism: | Hepatitis C virus |
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| Description: | B0B3F0 |
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| Residue: | 685 |
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| Sequence: | APITAYAQQTRGLLGTIVTSLTGRDKNVVTGEVQVLSTTTQTFLGTTVGGVMWTVYHGAG
SRTLAGAKHPALQMYTNVDQDLVGWPAPPGAKSLELCTCGSADLYLVTRDADVIPARRRG
DSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQAR
SPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGS
YMSRAHGIDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSI
LGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGGIPFYGKAIPIAQLE
GGRHLIFCHSRKKCDELASKLRGMGLNAVAYYRGLDVSVIPTVGDVVVCATDALMTGFTG
DFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRPSTYRYVTPGE
RPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVWQDHLDFWESVFTGLT
HIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDEMWKCLVRLKPTLHGPTPLLY
RLGPIQNEICLTHPITKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGCVVIVGHI
ELGGKPALVPDKEVLYQQYDEMEEC
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| BDBM124110 |
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| n/a |
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| Name | BDBM124110 |
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| Synonyms: | US8754105, 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33ClN4O8S |
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| Mol. Mass. | 633.112 |
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| SMILES | COc1ccc2c(O[C@@H]3C[C@@H]4N(C3)C(=O)OCCCC\C=C/[C@@H]3C[C@]3(NC4=O)C(=O)NS(=O)(=O)C3CC3)nc(Cl)cc2c1 |r,c:21| |
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| Structure | 
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