| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 6 |
|---|
| Ligand | BDBM124233 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | pNPP assay |
|---|
| IC50 | 3.876e+4± 3.39e+3 nM |
|---|
| Citation |  Wang, WL; Huang, C; Gao, LX; Tang, CL; Wang, JQ; Wu, MC; Sheng, L; Chen, HJ; Nan, FJ; Li, JY; Li, J; Feng, B Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors. Bioorg Med Chem Lett24:1889-94 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 6 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 6 |
|---|
| Synonyms: | HCP | PTN6_HUMAN | PTP1C | PTPN6 | Protein tyrosine phosphatase SHP-1 (SHP-1) | Protein-tyrosine phosphatase 1C | Protein-tyrosine phosphatase SHP-1 | Src homology phosphatase 1 (SHP-1) | Tyrosine-protein phosphatase non-receptor type 6 | Tyrosine-protein phosphatase non-receptor type 6 (SHP1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 67570.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29350 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
|
|
|
|---|
| BDBM124233 |
|---|
| n/a |
|---|
| Name | BDBM124233 |
|---|
| Synonyms: | N‐{4‐[4‐(furan‐2‐amido)phenyl]phenyl}furan‐2‐ carboxamide (1) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H16N2O4 |
|---|
| Mol. Mass. | 372.3734 |
|---|
| SMILES | O=C(Nc1ccc(cc1)-c1ccc(NC(=O)c2ccco2)cc1)c1ccco1 |
|---|
| Structure | 
|
|---|
Search and Browse
