| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM124259 |
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| Substrate/Competitor | n/a |
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| IC50 | 2.04e+4± 2.47e+3 nM |
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| Citation |  Yin, JP; Tang, CL; Gao, LX; Ma, WP; Li, JY; Li, Y; Li, J; Nan, FJ Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors. Org Biomol Chem12:3441-5 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM124259 |
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| n/a |
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| Name | BDBM124259 |
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| Synonyms: | (1R,6R,7S,10S,11R,12S)-6-dodecyl-7-(hydroxymethyl)-1,10-dimethyl-2,9,13-trioxatetracyclo[8.2.1.0⁴,.0⁷,]tridec-4-ene-3,8-dione (15) |
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| Type | Small organic molecule |
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| Emp. Form. | C25H38O6 |
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| Mol. Mass. | 434.5656 |
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| SMILES | CCCCCCCCCCCC[C@@H]1C=C2[C@@H]3[C@H]4[C@](C)(OC(=O)[C@@]14CO)O[C@]3(C)OC2=O |r,c:13| |
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| Structure | 
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