Reaction Details |
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Target | Hematopoietic prostaglandin D synthase |
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Ligand | BDBM124922 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibiting Action |
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pH | 8±n/a |
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IC50 | 15±n/a nM |
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Comments | extracted |
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Citation | Urade, Y; Kitade, M; Shigeno, K; Yamane, K; Tanaka, K Piperazine compound having a PGDS inhibitory effect US Patent US8765750 Publication Date 7/1/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Hematopoietic prostaglandin D synthase |
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Name: | Hematopoietic prostaglandin D synthase |
Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
Type: | Enzyme |
Mol. Mass.: | 23341.07 |
Organism: | Homo sapiens (Human) |
Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
Residue: | 199 |
Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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BDBM124922 |
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n/a |
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Name | BDBM124922 |
Synonyms: | US8765750, 7 |
Type | Small organic molecule |
Emp. Form. | C27H35N7O2 |
Mol. Mass. | 489.6125 |
SMILES | CC1C=CC=C1C(=O)N1CCN(CC1)C(=O)NC1CCN(CC1)c1ccc(CCn2ccnn2)cc1 |c:2,4| |
Structure |
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