| Reaction Details |
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 | Report a problem with these data |
| Target | Hematopoietic prostaglandin D synthase |
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| Ligand | BDBM124924 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibiting Action |
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| pH | 8±n/a |
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| IC50 | 61±n/a nM |
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| Comments | extracted |
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| Citation |  Urade, Y; Kitade, M; Shigeno, K; Yamane, K; Tanaka, K Piperazine compound having a PGDS inhibitory effect US Patent US8765750 Publication Date 7/1/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Hematopoietic prostaglandin D synthase |
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| Name: | Hematopoietic prostaglandin D synthase |
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| Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23341.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
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| Residue: | 199 |
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| Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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| BDBM124924 |
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| n/a |
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| Name | BDBM124924 |
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| Synonyms: | US8765750, 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H41N7O2 |
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| Mol. Mass. | 531.6922 |
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| SMILES | CC1C=CC=C1C(=O)N1CCN(CC1)C(=O)NC1CCN(CC1)c1ccc(CCCn2nc(C)nc2C)cc1 |c:2,4| |
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| Structure | 
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