Ki Summary

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Target

Cyclin-T1

Ligand

BDBM126530

Substrate/Competitor

n/a

Meas. Tech.

IMAP Assay

IC50

0.00015±n/a nM

Citation

Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent US8778951 Publication Date 7/15/2014

More Info.:

Get all data from this article, Assay Method

Cyclin-T1

Name:

Cyclin-T1

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

80712.40

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

726

Sequence:

MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK

BDBM126530

n/a

Name

BDBM126530

Synonyms:

US8778951, 341

Type

Small organic molecule

Emp. Form.

C23H28ClFN6O

Mol. Mass.

458.959

SMILES

N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2(CCOCC2)C#N)n1 |r,wU:4.7,wD:1.0,(4.84,1.68,;3.51,2.45,;3.51,3.99,;2.18,4.76,;.84,3.99,;.84,2.45,;2.18,1.68,;-.49,4.76,;-1.82,3.99,;-1.82,2.45,;-3.16,1.68,;-4.49,2.45,;-5.82,1.68,;-4.49,3.99,;-3.16,4.76,;-3.16,.14,;-4.49,-.63,;-4.49,-2.17,;-3.16,-2.94,;-3.16,-4.48,;-1.82,-2.17,;-.49,-2.94,;.84,-2.17,;2.18,-2.94,;2.18,-4.48,;3.51,-5.25,;4.84,-4.48,;4.84,-2.94,;3.51,-2.17,;2.18,-1.4,;2.18,.14,;-1.82,-.63,)|

Structure